Department of Community & Family Medicine
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Faculty Listing
Faculty Portrait

Joellen Martha Schildkraut, PhD, MPH

Professor of Community and Family Medicine
Associate Professor of Medicine

Department / Division
Community and Family Medicine / Prevention Research

Address:
6036 Hock Plaza
2424 Erwin Road
Durham, NC 27705

Office Telephone:
(919) 681-4761

Training:

  • PhD, Yale University, 1987
  • MPH, Yale University, 1982

Research Interests:
Dr. Schildkraut is an epidemiologist whose research includes the molecular epidemiology of ovarian, breast and brain cancers. Dr. Schildkraut's research interests include the study of the interaction between genetic and environmental factors. She is currently involved in a large study of genome wide association and ovarian cancer risk and survival. Some of her work is also focused on particular genetic pathways including the DNA repair and apoptosis pathways. She currently leads a study of African American women diagnosed with ovarian cancer. She is also collaborating in a large a case-control study of meningioma risk factors and with which a genome wide association analysis is about to commence.

Publications:

  • Doherty, JA; Rossing, MA; Cushing-Haugen, KL; Chen, C; Van Den Berg, DJ; Wu, AH; Pike, MC; Ness, RB; Moysich, K; Chenevix-Trench, G; Beesley, J; Webb, PM; Chang-Claude, J; Wang-Gohrke, S; Goodman, MT; Lurie, G; Thompson, PJ; Carney, ME; Hogdall, E; Kjaer, SK; Hogdall, C; Goode, EL; Cunningham, JM; Fridley, BL; Vierkant, RA; Berchuck, A; Moorman, PG; Schildkraut, JM; Palmieri, RT; Cramer, DW; Terry, KL; Yang, HP; Garcia-Closas, M; Chanock, S; Lissowska, J; Song, H; Pharoah, PD; Shah, M; Perkins, B; McGuire, V; Whittemore, AS; Di Cioccio, RA; Gentry-Maharaj, A; Menon, U; Gayther, SA; Ramus, SJ; Ziogas, A; Brewster, W; Anton-Culver, H; Australian Ovarian Cancer Study Management Group, ; Australian Cancer Study (Ovarian Cancer), ; Pearce, CL; Ovarian Cancer Association Consortium (OCAC). ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study. Cancer Epidemiology, Biomarkers and Prevention. 2010;19:245-250. Abstract

  • Goode, EL; Maurer, MJ; Sellers, TA; Phelan, CM; Kalli, KR; Fridley, BL; Vierkant, RA; Armasu, SM; White, KL; Keeney, GL; Cliby, WA; Rider, DN; Kelemen, LE; Jones, MB; Peethambaram, PP; Lancaster, JM; Olson, JE; Schildkraut, JM; Cunningham, JM; Hartmann, LC. Inherited determinants of ovarian cancer survival. Clinical Cancer Research. 2010;16:995-1007. Abstract

  • Peedicayil, A; Vierkant, RA; Hartmann, LC; Fridley, BL; Fredericksen, ZS; White, KL; Elliott, EA; Phelan, CM; Tsai, YY; Berchuck, A; Iversen, ES; Couch, FJ; Peethamabaran, P; Larson, MC; Kalli, KR; Kosel, ML; Shridhar, V; Rider, DN; Liebow, M; Cunningham, JM; Schildkraut, JM; Sellers, TA; Goode, EL. Risk of ovarian cancer and inherited variants in relapse-associated genes. PLoS One. 2010;5:e8884. Abstract

  • Phelan, CM; Tsai, YY; Goode, EL; Vierkant, RA; Fridley, BL; Beesley, J; Chen, XQ; Webb, PM; Chanock, S; Cramer, DW; Moysich, K; Edwards, RP; Chang-Claude, J; Garcia-Closas, M; Yang, H; Wang-Gohrke, S; Hein, R; Green, AC; Lissowska, J; Carney, ME; Lurie, G; Wilkens, LR; Ness, RB; Pearce, CL; Wu, AH; Van Den Berg, DJ; Stram, DO; Terry, KL; Whiteman, DC; Whittemore, AS; DiCioccio, RA; McGuire, V; Doherty, JA; Rossing, MA; Anton-Culver, H; Ziogas, A; Hogdall, C; Hogdall, E; Kr├╝ger Kjaer, S; Blaakaer, J; Quaye, L; Ramus, SJ; Jacobs, I; Song, H; Pharoah, PD; Iversen, ES; Marks, JR; Pike, MC; Gayther, SA; Cunningham, JM; Goodman, MT; Schildkraut, JM; Chenevix-Trench, G; Berchuck, A; Sellers, TA; Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer), ; Australian Ovarian . . . Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. Cancer Epidemiology, Biomarkers and Prevention. 2010;19:600-604. Abstract

  • White, KL; Sellers, TA; Fridley, BL; Vierkant, RA; Phelan, CM; Tsai, YY; Kalli, KR; Berchuck, A; Iversen, ES; Hartmann, LC; Liebow, M; Armasu, S; Fredericksen, Z; Larson, MC; Duggan, D; Couch, FJ; Schildkraut, JM; Cunningham, JM; Goode, EL. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. Twin Research and Human Genetics. 2010;13:43-56. Abstract

  • Fasching, PA; Gayther, S; Pearce, L; Schildkraut, JM; Goode, E; Thiel, F; Chenevix-Trench, G; Chang-Claude, J; Wang-Gohrke, S; Ramus, S; Pharoah, P; Berchuck, A; OCAC (Ovarian Cancer Association Consortium). Role of genetic polymorphisms and ovarian cancer susceptibility. Molecular Oncology. 2009;3:171-181. Abstract

  • Goode, EL; Fridley, BL; Vierkant, RA; Cunningham, JM; Phelan, CM; Anderson, S; Rider, DN; White, KL; Pankratz, VS; Song, H; Hogdall, E; Kjaer, SK; Whittemore, AS; DiCioccio, R; Ramus, SJ; Gayther, SA; Schildkraut, JM; Pharaoh, PP; Sellers, TA. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. Cancer Epidemiology, Biomarkers and Prevention. 2009;18:935-944. Abstract

  • Hoyo, C; Grubber, J; Demark-Wahnefried, W; Lobaugh, B; Jeffreys, AS; Grambow, SC; Marks, JR; Keku, TO; Walther, PJ; Schildkraut, JM. Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. Journal of the National Medical Association. 2009;101:711-716. Abstract

  • Hoyo, C; Schildkraut, JM; Murphy, SK; Chow, WH; Vaughan, TL; Risch, H; Marks, JR; Jirtle, RL; Calingaert, B; Mayne, S; Fraumeni, J; Gammon, MD. IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas. International Journal of Cancer. 2009;125:2673-2678. Abstract

  • Il'yasova, D; McCarthy, B; Marcello, J; Schildkraut, JM; Moorman, PG; Krishnamachari, B; Ali-Osman, F; Bigner, DD; Davis, F. Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls. Cancer Epidemiology, Biomarkers and Prevention. 2009;18:1232-1238. Abstract

  • Moorman, PG; Palmieri, RT; Akushevich, L; Berchuck, A; Schildkraut, JM. Ovarian cancer risk factors in African-American and white women. American Journal of Epidemiology. 2009;170:598-606. Abstract

  • Moorman, PG; Schildkraut, JM; Iversen, ES; Myers, ER; Gradison, M; Warren-White, N; Wang, F. A prospective study of weight gain after premenopausal hysterectomy. Journal of Women's Health. 2009;18:699-708. Abstract

  • Pearce, CL; Near, AM; Van Den Berg, DJ; Ramus, SJ; Gentry-Maharaj, A; Menon, U; Gayther, SA; Anderson, AR; Edlund, CK; Wu, AH; Chen, X; Beesley, J; Webb, PM; Holt, SK; Chen, C; Doherty, JA; Rossing, MA; Whittemore, AS; McGuire, V; DiCioccio, RA; Goodman, MT; Lurie, G; Carney, ME; Wilkens, LR; Ness, RB; Moysich, KB; Edwards, R; Jennison, E; Kjaer, SK; Hogdall, E; Hogdall, CK; Goode, EL; Sellers, TA; Vierkant, RA; Cunningham, JM; Schildkraut, JM; Berchuck, A; Moorman, PG; Iversen, ES; Cramer, DW; Terry, KL; Vitonis, AF; Titus-Ernstoff, L; Song, H; Pharoah, PD; Spurdle, AB; Anton-Culver, H; Ziogas, A; Brewster, W; Galitovskiy, V; Chenevix-Trench, G; Australian Cancer Study, ; Australian Ovarian Cancer Study Group. Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. British Journal of Cancer. 2009;100:412-420. Abstract

  • Peedicayil, A; Vierkant, RA; Shridhar, V; Schildkraut, JM; Armasu, S; Hartmann, LC; Fridley, BL; Cunningham, JM; Phelan, CM; Sellers, TA; Goode, EL. Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. Gynecologic Oncology. 2009;114:260-264. Abstract

  • Quaye, L; Tyrer, J; Ramus, SJ; Song, H; Wozniak, E; DiCioccio, RA; McGuire, V; H├Şgdall, E; H├Şgdall, C; Blaakaer, J; Goode, EL; Schildkraut, JM; Easton, DF; Kr├╝ger-Kjaer, S; Whittemore, AS; Gayther, SA; Pharoah, PD. Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. PLoS One. 2009;4:e5983. Abstract

  • Schildkraut, JM; Goode, EL; Clyde, MA; Iversen, ES; Moorman, PG; Berchuck, A; Marks, JR; Lissowska, J; Brinton, L; Peplonska, B; Cunningham, JM; Vierkant, RA; Rider, DN; Chenevix-Trench, G; Webb, PM; Beesley, J; Chen, X; Phelan, C; Sutphen, R; Sellers, TA; Pearce, L; Wu, AH; Van Den Berg, D; Conti, D; Elund, CK; Anderson, R; Goodman, MT; Lurie, G; Carney, ME; Thompson, PJ; Gayther, SA; Ramus, SJ; Jacobs, I; Kr├╝ger Kjaer, S; Hogdall, E; Blaakaer, J; Hogdall, C; Easton, DF; Song, H; Pharoah, PD; Whittemore, AS; McGuire, V; Quaye, L; Anton-Culver, H; Ziogas, A; Terry, KL; Cramer, DW; Hankinson, SE; Tworoger, SS; Calingaert, B; Chanock, S; Sherman, M; Garcia-Closas, M; Australian Ovarian Cancer Study Group. Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. Cancer Research. 2009;69:2349-2357. Abstract

  • Song, H; Ramus, SJ; Kjaer, SK; DiCioccio, RA; Chenevix-Trench, G; Pearce, CL; Hogdall, E; Whittemore, AS; McGuire, V; Hogdall, C; Blaakaer, J; Wu, AH; Van Den Berg, DJ; Stram, DO; Menon, U; Gentry-Maharaj, A; Jacobs, IJ; Webb, PM; Beesley, J; Chen, X; Australian Cancer (Ovarian) Study, ; Australian Ovarian Cancer Study Group, ; Rossing, MA; Doherty, JA; Chang-Claude, J; Wang-Gohrke, S; Goodman, MT; Lurie, G; Thompson, PJ; Carney, ME; Ness, RB; Moysich, K; Goode, EL; Vierkant, RA; Cunningham, JM; Anderson, S; Schildkraut, JM; Berchuck, A; Iversen, ES; Moorman, PG; Garcia-Closas, M; Chanock, S; Lissowska, J; Brinton, L; Anton-Culver, H; Ziogas, A; Brewster, WR; Ponder, BA; Easton, DF; Gayther, SA; Pharoah, PD; Ovarian Cancer Association Consortium (OCAC). Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Human Molecular Genetics. 2009;18:2297-2304. Abstract

  • Song, H; Ramus, SJ; Tyrer, J; Bolton, KL; Gentry-Maharaj, A; Wozniak, E; Anton-Culver, H; Chang-Claude, J; Cramer, DW; DiCioccio, R; D├Ârk, T; Goode, EL; Goodman, MT; Schildkraut, JM; Sellers, T; Baglietto, L; Beckmann, MW; Beesley, J; Blaakaer, J; Carney, ME; Chanock, S; Chen, Z; Cunningham, JM; Dicks, E; Doherty, JA; D├╝rst, M; Ekici, AB; Fenstermacher, D; Fridley, BL; Giles, G; Gore, ME; De Vivo, I; Hillemanns, P; Hogdall, C; Hogdall, E; Iversen, ES; Jacobs, IJ; Jakubowska, A; Li, D; Lissowska, J; Lubi┬┐ski, J; Lurie, G; McGuire, V; McLaughlin, J; Medrek, K; Moorman, PG; Moysich, K; Narod, S; Phelan, C; Pye, C; Risch, H; Runnebaum, IB; Severi, G; Southey, M; Stram, DO; Thiel, FC; Terry, KL; Tsai, YY; Tworoger, SS; Van Den Berg, DJ; Vierkant, RA; Wang-Gohrke, S; Webb, PM; Wilkens, LR; Wu, A. . . A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nature Genetics. 2009;41:996-1000. Abstract

  • White, KL; Vierkant, RA; Phelan, CM; Fridley, BL; Anderson, S; Knutson, KL; Schildkraut, JM; Cunningham, JM; Kelemen, LE; Pankratz, VS; Rider, DN; Liebow, M; Hartmann, LC; Sellers, TA; Goode, EL. Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer. BMC Cancer. 2009;9:170. Abstract

  • Berchuck, A; Schildkraut, JM; Pearce, CL; Chenevix-Trench, G; Pharoah, PD. Role of genetic polymorphisms in ovarian cancer susceptibility: development of an international ovarian cancer association consortium. Advances in Experimental Medicine and Biology. 2008;622:53-67. Abstract

  • Cunningham, JM; Sellers, TA; Schildkraut, JM; Fredericksen, ZS; Vierkant, RA; Kelemen, LE; Gadre, M; Phelan, CM; Huang, Y; Meyer, JG; Pankratz, VS; Goode, EL. Performance of amplified DNA in an Illumina GoldenGate BeadArray assay. Cancer Epidemiology, Biomarkers and Prevention. 2008;17:1781-1789. Abstract

  • Kelemen, LE; Sellers, TA; Schildkraut, JM; Cunningham, JM; Vierkant, RA; Pankratz, VS; Fredericksen, ZS; Gadre, MK; Rider, DN; Liebow, M; Goode, EL. Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. Cancer Research. 2008;68:2498-2506. Abstract

  • Moorman, PG; Calingaert, B; Palmieri, RT; Iversen, ES; Bentley, RC; Halabi, S; Berchuck, A; Schildkraut, JM. Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women. American Journal of Epidemiology. 2008;167:1059-1069. Abstract

  • Neklason, DW; Kerber, RA; Nilson, DB; Anton-Culver, H; Schwartz, AG; Griffin, CA; Lowery, JT; Schildkraut, JM; Evans, JP; Tomlinson, GE; Strong, LC; Miller, AR; Stopfer, JE; Finkelstein, DM; Nadkarni, PM; Kasten, CH; Mineau, GP; Burt, RW. Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Research. 2008;68:8993-8997. Abstract

  • Palmieri, RT; Wilson, MA; Iversen, ES; Clyde, MA; Calingaert, B; Moorman, PG; Poole, C; Anderson, AR; Anderson, S; Anton-Culver, H; Beesley, J; Hogdall, E; Brewster, W; Carney, ME; Chen, X; Chenevix-Trench, G; Chang-Claude, J; Cunningham, JM; Dicioccio, RA; Doherty, JA; Easton, DF; Edlund, CK; Gayther, SA; Gentry-Maharaj, A; Goode, EL; Goodman, MT; Kjaer, SK; Hogdall, CK; Hopkins, MP; Jenison, EL; Blaakaer, J; Lurie, G; McGuire, V; Menon, U; Moysich, KB; Ness, RB; Pearce, CL; Pharoah, PD; Pike, MC; Ramus, SJ; Rossing, MA; Song, H; Terada, KY; Vandenberg, D; Vierkant, RA; Wang-Gohrke, S; Webb, PM; Whittemore, AS; Wu, AH; Ziogas, A; Berchuck, A; Schildkraut, JM; Ovarian Cancer Association Consortium, ; Australian Cancer Study (Ovarian Cancer Group), ; Australian Ovarian Cancer Study Group. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Cancer Epidemiology, Biomarkers and Prevention. 2008;17:3567-3572. Abstract

  • Potthoff, RF; Halabi, S; Schildkraut, JM; Newman, B. Flexible Frames and Control Sampling in Case-Control Studies: Weighters (Survey Statisticians) Versus Anti-Weighters (Epidemiologists). American Statistician. 2008;62:307-313. Abstract

  • Ramus, SJ; Vierkant, RA; Johnatty, SE; Pike, MC; Van Den Berg, DJ; Wu, AH; Pearce, CL; Menon, U; Gentry-Maharaj, A; Gayther, SA; Dicioccio, RA; McGuire, V; Whittemore, AS; Song, H; Easton, DF; Pharoah, PD; Garcia-Closas, M; Chanock, S; Lissowska, J; Brinton, L; Terry, KL; Cramer, DW; Tworoger, SS; Hankinson, SE; Berchuck, A; Moorman, PG; Schildkraut, JM; Cunningham, JM; Liebow, M; Kjaer, SK; Hogdall, E; Hogdall, C; Blaakaer, J; Ness, RB; Moysich, KB; Edwards, RP; Carney, ME; Lurie, G; Goodman, MT; Wang-Gohrke, S; Kropp, S; Chang-Claude, J; Australian Ovarian Cancer Study Group, ; Australian Cancer Study (Ovarian Cancer), ; Webb, PM; Chen, X; Beesley, J; Chenevix-Trench, G; Goode, EL; Ovarian Cancer Association Consortium. Consortium analysis of 7 candidate SNPs for ovarian cancer. International Journal of Cancer. 2008;123:380-388. Abstract

  • Schildkraut, JM; Moorman, PG; Bland, AE; Halabi, S; Calingaert, B; Whitaker, R; Lee, PS; Elkins-Williams, T; Bentley, RC; Marks, JR; Berchuck, A. Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup. Cancer Epidemiology, Biomarkers and Prevention. 2008;17:585-593. Abstract

  • Sellers, TA; Huang, Y; Cunningham, J; Goode, EL; Sutphen, R; Vierkant, RA; Kelemen, LE; Fredericksen, ZS; Liebow, M; Pankratz, VS; Hartmann, LC; Myer, J; Iversen, ES; Schildkraut, JM; Phelan, C. Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer. Cancer Epidemiology, Biomarkers and Prevention. 2008;17:397-404. Abstract

  • Skinner, CS; Schildkraut, JM; Calingaert, B; Hoyo, C; Crankshaw, SS; Fish, L; Susswein, L; Jasper, C; Reid, L. Factors associated with African Americans' enrollment in a national cancer genetics registry. Community Genetics. 2008;11:224-233. Abstract

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